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Summary
Semi-final 1
| Rank | Name | Nation | Time |
| 1 | Evelyn Ashford | USA | 10.99 |
| 2 | Anelia Vetchernikova | BUL | 11.00 |
| 3 | Gwen Torrence | USA | 11.02 |
| 4 | Juliet Cuthbert | JAM | 11.10 |
| 5 | Silke Moeller | GDR | 11.12 |
| 6 | Marlies Gohr | GDR | 11.13 |
| 7 | Lioudmila Kondratieva | URS | 11.21 |
| 8 | Marina Jirova | URS | 11.24 |
| Rank | Name | Nation | Time |
| 1 | Florence Griffith Joyner | USA | 10.70 |
| 2 | Heike Drechsler | GDR | 10.91 |
| 3 | Natalia Pomochtchnikova | URS | 11.03 |
| 4 | Grace Jackson | JAM | 11.06 |
| 5 | Ulrike Sarvari | FRG | 11.12 |
| 6 | Pauline Davis | BAH | 11.12 |
| 7 | Nelli Cooman | NED | 11.13 |
| Did not start | |||
| Merlene Ottey | JAM | ||