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Date: 29 September 1988 / 30 September 1988
Heats
Quarter-finals
Semi-finals
Final
| Rank | Name | Nation | Time |
| 1 | Yordanka Donkova | BUL | 12.38 |
| 2 | Gloria Siebert | GDR | 12.61 |
| 3 | Claudia Zackiewicz | FRG | 12.75 |
| 4 | Natalya Grigoryeva | URS | 12.79 |
| 5 | Florence Colle | FRA | 12.98 |
| 6 | Julie Rocheleau | CAN | 12.99 |
| 7 | Monique Ewanje-Epee | FRA | 13.14 |
| 8 | Cornelia Oschkenat | GDR | 13.73 |
| Semi-finals | |||
| 9 | Kerstin Knabe | GDR | 12.93 |
| 10 | Marjan Olyslager | NED | 13.08 |
| 11 | Sally Gunnell | GBR | 13.13 |
| 12 | Lesley-Ann Skeete | GBR | 13.23 |
| 13 | LaVonna Martin | USA | 13.29 |
| 14 | Gail Devers-Roberts | USA | 13.51 |
| 15 | Jacqueline Humphrey | USA | 13.59 |
| 16 | Lyudmila Narozhilenko | URS | |
| Quarter-finals | |||
| 17 | Wendy Jeal | GBR | 13.32 |
| 18 | Gretha Tromp | NED | 13.42 |
| 19 | Du Juan | CHN | 13.58 |
| 20 | Rita Heggli | SUI | 13.95 |
| 21 | Liu Huajin | CHN | 14.37 |
| 22 | Maria Usifo | NGR | |
| 22 | Anne Piguereau | FRA | |
| 24 | Jane Flemming | AUS | |
| Heats | |||
| 25 | Dinah Yankey | GHA | 13.64 |
| 26 | Sandra Tavares | MEX | 13.81 |
| 27 | Bang Sin-Hye | KOR | 13.84 |
| 28 | Nancy Vallecilla | ECU | 13.97 |
| 29 | Chen Wen-Ing | TPE | 14.04 |
| 30 | Suet Yee Cheung | HKG | 14.26 |
| 31 | Agripina De La Cruz | PHI | 14.36 |
| 32 | Manuela Marxer | LIE | 14.38 |
| 33 | Sainiana Tukana | FIJ | 15.50 |
| Did not finish | |||
| Ginka Zagorcheva | BUL | ||
| Disqualified | |||
| Sylvia Dethier | BEL | ||
| Tilaka Jinadasa | SRI | ||
| Did not start | |||
| Michelle Johnson | VIN | ||