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Date: 25 July 1980 / 26 July 1980
Heats
Quarter-finals
Semi-finals
Final
| Rank | Name | Nation | Time |
| 1 | Liudmila Kondratieva | URS | 11.06 |
| 2 | Marlies Gohr | GDR | 11.07 |
| 3 | Ingrid Auerswald | GDR | 11.14 |
| 4 | Linda Haglund | SWE | 11.16 |
| 5 | Romy Muller | GDR | 11.16 |
| 6 | Kathy Smallwood | GBR | 11.28 |
| 7 | Chantal Rega | FRA | 11.32 |
| 8 | Heather Hunte | GBR | 11.34 |
| Semi-finals | |||
| 9 | Sonia Lannaman | GBR | 11.38 |
| 9 | Natalia Bochina | URS | 11.38 |
| 11 | Sofka Popova | BUL | 11.40 |
| 12 | Denise Boyd | AUS | 11.44 |
| 13 | Vera Anisimova | URS | 11.51 |
| 14 | Emma Sulter | FRA | 11.63 |
| 15 | Maria Shishkova | BUL | 11.65 |
| 16 | Laureen Beckles | FRA | 11.70 |
| Quarter-finals | |||
| 17 | Obuzoeme Nsenu | NGR | 11.55 |
| 18 | Brigitte Senglaub | SUI | 11.56 |
| 19 | Marisa Masullo | ITA | 11.57 |
| 20 | Rufina Uba | NGR | 11.60 |
| 21 | Deborah Wells | AUS | 11.66 |
| 22 | Rose Allwood | JAM | 11.69 |
| 23 | Helina Laihorinne | FIN | |
| 23 | Els Vader | NED | |
| Heats | |||
| 25 | Nzaeli Kyomo | TAN | 11.77 |
| 26 | Jennifer Innis | GUY | 11.79 |
| 26 | Leleith Hodges | JAM | 11.79 |
| 28 | Carmela Bolivar | PER | 12.07 |
| 29 | Francoise Odette Damado | SEN | 12.16 |
| 30 | Mosi Ali | TAN | 12.19 |
| 31 | Usha Rilavulakandi | IND | 12.27 |
| 32 | Ruth Enang | CMR | 12.40 |
| 33 | Marieme Boye | SEN | 12.42 |
| 34 | Eugenia Osho-Williams | SLE | 12.95 |
| 35 | Bessy de Letourdie | SEY | 13.04 |
| 36 | Edwige Bancole | BEN | 13.19 |
| 37 | Estella Meheux | SLE | 13.22 |
| 38 | Thanh Van Tran | VIE | 13.23 |
| 39 | Khampaseuth | LAO | 14.62 |
| Disqualified | |||
| Elzbieta Stachurska | POL | ||