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Date: 20 July 1980 / 20 July 1980
Heats
Final
| Rank | Name | Nation | Time |
| 1 | Rica Reinisch; Ute Geweniger; Andrea Pollack; Caren Metschuck { + Sarina Huelsenbeck} | GDR | 4:06.67 |
| 2 | Helen Jameson; Margaret Kelly; Ann Osgerby; June Croft | GBR | 4:12.24 |
| 3 | Elena Kruglova; Elvira Vasilkova; Alla Grishchenkova; Natalia Strunnikova { + Irina Aksenova; Olga Klevakina} | URS | 4:13.61 |
| 4 | Annika Uvehall; Eva-Marie Hakansson; Agneta Mortensson; Tina Gustafsson | SWE | 4:16.91 |
| 5 | Laura Foralosso; Sabrina Seminatore; Cinzia Savi Scarponi; Monica Vallarin | ITA | 4:19.05 |
| 6 | Lisa Forrest; Lisa Curry; Karen van de Graaf; Rosemary Brown | AUS | 4:19.90 |
| 7 | Carmen Bunaciu; Brigitte Prass; Mariana Paraschiv; Irinel Adela Panulescu | ROU | 4:21.27 |
| 8 | Stoianka Dyngalakova; Tania Bogomilova; Ani Moneva; Dobrinka Mincheva | BUL | 4:22.38 |
| Heats | |||
| 9 | Teresa Rivera; Elke Holtz; Dagmar Erdman; Hellen Plaschinski | MEX | 4:25.95 |
| 10 | Yolande van der Straeten; Brigitte Bosmans; Carine Verbauwen; Pascale Verbauwen | BEL | 4:26.33 |